Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men
Table 2
Correlation of T2DM and T2DM + CHD estimated by binary regression analyses.
Groups
Trp/Trp (%)
Trp/Arg (%)
Arg/Arg (%)
MAF
Dominant model (allelic)
Adjusted log-dominant mode
OR (95% CI)
P value
OR (95% CI)
P value
All
Control
346
101 (29.19)
166 (47.98)
79 (22.83)
0.4682
1.00
1.00
T2DM
312
80 (25.64)
153 (49.04)
79 (25.32)
0.4984
1.2154 (0.8613–1.7149)
0.2939
1.332 (0.369–4.811)
0.6611
T2DM + CHD
288
74 (25.69)
141 (48.96)
73 (25.35)
0.4983
1.212 (0.8524–1.7231)
0.3261
1.703 (0.714–7.2969)
0.4083
Males
Control
170
52 (30.59)
79 (46.47)
39 (22.94)
0.4618
1.00
T2DM
158
32 (20.25)
81 (51.27)
45 (28.48)
0.5411
1.7352 (1.0452–2.8807)
0.0425
3.838 (0.538–27.385)
<0.01
T2DM + CHD
144
28 (19.44)
75 (52.08)
41 (28.47)
0.5451
1.7755 (1.048–3.008)
0.0368
5.213 (1.006–27.005)
<0.01
Females
Control
176
53 (30.11)
86 (48.86)
37 (21.02)
0.4545
1.00
1.00
T2DM
154
48 (31.17)
72 (46.75)
34 (22.08)
0.4545
0.9516 (0.5953–1.521)
0.9048
0.934 (0.304–2.875)
0.9053
T2DM + CHD
144
46 (31.94)
66 (45.83)
32 (22.22)
0.4514
0.918 (0.5704–1.4774)
0.8080
0.985 (0.564–1.720)
0.9582
OR = odds ratio; 95% CI = 95% confidence interval; MAF = minor allele frequency; allele frequencies were estimated by direct counting. ∗Adjusted for age, BMI, smoking status, alcohol status, hypertension, TC, LDL-C, and hs-CRP. T2DM, type 2 diabetes mellitus; CHD, coronary heart disease.
