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Journal of Diabetes Research
Volume 2014 (2014), Article ID 920134, 12 pages
http://dx.doi.org/10.1155/2014/920134
Review Article

The Role of MicroRNAs in Diabetic Nephropathy

1Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
2Chinese-American Research Institute for Diabetic Complications at Wenzhou Medical University, Wenzhou 325035, China
3Kosair Children’s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
4Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China
5State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China

Received 7 June 2014; Accepted 29 July 2014; Published 1 September 2014

Academic Editor: Konstantinos Papatheodorou

Copyright © 2014 Hao Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.