The Role of MicroRNAs in Diabetic Nephropathy

Table 2

Downregulated miRNAs.

miRNAs	Targets	Biological outcome	Models	References
miR-200a/miR-141	TGF-β2	COL1, COL4, FN ↓	NRK52E cells	[54]
miR-29a/b/c	COL1,; COL4	COL1, COL4 ↓	NRK52E cells, MMCs, human podocytes	[56]
miR-29a	COL41/2; HDAC4	COL1, COL4 ↓; Podocytes dysfunction ↓	HK-2 cells; miR-29a transgenic mice; Podocytes	[57]; [58]
miR-29b		TGF-β/SMAD3, Sp1/NF-κB ↓	db/db mice	[4]
miR-451	YWHAZ	p38MAPK, ECM ↓	MMCs	[60]
miR-25	NOX4	NOX4 ↓	RMCs	[66]
miR-93	VEGF-A	VEGF, COL43, FN ↓	db/db mice, podocytes, renal microvascular; endothelial cells	[67]
Let-7b	TGFBR1	SMAD3, ECM ↓	Diabetic mice (STZ), NRK52E cells	[68]

TGFBR1: transforming growth factor beta receptor 1; VEGF-A: vascular endothelial growth factor A; Sp1: specificity protein 1; HDAC4: histone deacetylase 4; YWHAZ: tyrosine 3 monooxygenase/tryptophan 5-monooxygenase activation protein, zeta; NOX4: NADPH oxidase subunit 4; NRK52E cells: rat renal proximal tubular cell line.