Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2014 (2014), Article ID 953740, 7 pages
http://dx.doi.org/10.1155/2014/953740
Research Article

Injury to the Endothelial Surface Layer Induces Glomerular Hyperfiltration Rats with Early-Stage Diabetes

1Division of Endocrinology, Shanghai Tongji Hospital Affiliated Tongji University, No. 389, Xincun Road, Shanghai 200065, China
2Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
3Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200041, China

Received 14 January 2014; Accepted 27 March 2014; Published 9 April 2014

Academic Editor: Hiroshi Okamoto

Copyright © 2014 Chunyang Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Haraldsson, J. Nyström, and W. M. Deen, “Properties of the glomerular barrier and mechanisms of proteinuria,” Physiological Reviews, vol. 88, no. 2, pp. 451–487, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Haraldsson and J. Sörensson, “Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier,” News in Physiological Sciences, vol. 19, no. 1, pp. 7–10, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. A. R. Pries, T. W. Secomb, and P. Gaehtgens, “The endothelial surface layer,” Pflugers Archiv European Journal of Physiology, vol. 440, no. 5, pp. 653–666, 2000. View at Google Scholar · View at Scopus
  4. C. Hjalmarsson, B. R. Johansson, and B. Haraldsson, “Electron microscopic evaluation of the endothelial surface layer of glomerular capillaries,” Microvascular Research, vol. 67, no. 1, pp. 9–17, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Weinbaum, J. M. Tarbell, and E. R. Damiano, “The structure and function of the endothelial glycocalyx layer,” Annual Review of Biomedical Engineering, vol. 9, pp. 121–167, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Reitsma, D. W. Slaaf, H. Vink, M. A. M. J. Van Zandvoort, and M. G. A. Oude Egbrink, “The endothelial glycocalyx: composition, functions, and visualization,” Pflugers Archiv European Journal of Physiology, vol. 454, no. 3, pp. 345–359, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. F. E. Curry and R. H. Adamson, “Endothelial glycocalyx: permeability barrier and mechanosensor,” Annals of Biomedical Engineering, vol. 40, pp. 828–839, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. A. H. Salmon, J. K. Ferguson, J. L. Burford et al., “Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction,” Journal of the American Society of Nephrology, vol. 23, pp. 1339–1350, 2012. View at Google Scholar
  9. N. Besbas, D. Karpman, D. Landau et al., “A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders,” Kidney International, vol. 70, no. 3, pp. 423–431, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. S. A. Karumanchi, S. E. Maynard, I. E. Stillman, F. H. Epstein, and V. P. Sukhatme, “Preeclampsia: a renal perspective,” Kidney International, vol. 67, no. 6, pp. 2101–2113, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Jeansson and B. Haraldsson, “Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycan-degrading enzymes,” Journal of the American Society of Nephrology, vol. 14, no. 7, pp. 1756–1765, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Jeansson and B. Haraldsson, “Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier,” American Journal of Physiology—Renal Physiology, vol. 290, no. 1, pp. F111–F116, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Singh, S. C. Satchell, C. R. Neal, E. A. McKenzie, J. E. Tooke, and P. W. Mathieson, “Glomerular endothelial glycocalyx constitutes a barrier to protein permeability,” Journal of the American Society of Nephrology, vol. 18, no. 11, pp. 2885–2893, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. S. C. Satchell and J. E. Tooke, “What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?” Diabetologia, vol. 51, no. 5, pp. 714–725, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Nieuwdorp, H. L. Mooij, J. Kroon et al., “Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes,” Diabetes, vol. 55, no. 4, pp. 1127–1132, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Nieuwdorp, M. C. Meuwese, H. Vink, J. B. L. Hoekstra, J. J. P. Kastelein, and E. S. G. Stroes, “The endothelial glycocalyx: a potential barrier between health and vascular disease,” Current Opinion in Lipidology, vol. 16, no. 5, pp. 507–511, 2005. View at Google Scholar · View at Scopus
  17. A. Singh, V. Fridén, I. Dasgupta et al., “High glucose causes dysfunction of the human glomerular endothelial glycocalyx,” American Journal of Physiology—Renal Physiology, vol. 300, no. 1, pp. F40–F48, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Jeansson, A. B. Granqvist, J. S. Nyström, and B. Haraldsson, “Functional and molecular alterations of the glomerular barrier in long-term diabetes in mice,” Diabetologia, vol. 49, no. 9, pp. 2200–2209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Sörensson, M. Ohlson, K. Lindström, and B. Haraldsson, “Glomerular charge selectivity for horseradish peroxidase and albumin at low and normal ionic strengths,” Acta Physiologica Scandinavica, vol. 163, no. 1, pp. 83–91, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. J. M. Forbes, M. T. Coughlan, and M. E. Cooper, “Oxidative stress as a major culprit in kidney disease in diabetes,” Diabetes, vol. 57, no. 6, pp. 1446–1454, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Singh, R. D. Ramnath, R. R. Foster et al., “Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx,” PLOS ONE, vol. 8, no. 2, article e55852, 2013. View at Google Scholar