Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic db/db Mice by Inhibition of Hepatic Gluconeogenesis

Figure 1

Decrease of blood glucose levels and food intake in SA-treated db/db mice. Diabetic db/db mice were orally intubated with SA (10 mg kg⁻¹ body weight/day) or PBS for 8 weeks. (a) Blood levels of HbA1c, (b) nonfasting blood glucose levels, (c) fasting blood glucose levels, (d) food intake, and (e) body weights were measured. Untreated diabetic db/db mice and pair-fed diabetic db/db mice served as controls. –11 per group. , compared with PBS-treated mice; , compared with the pair-fed group; , compared with untreated mice.

(a)

(b)

(c)

(d)

(e)