Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic db/db Mice by Inhibition of Hepatic Gluconeogenesis

Figure 2

SA improved glucose tolerance in diabetic db/db mice. Diabetic db/db mice were orally intubated with SA (10 mg kg⁻¹ body weight/day) or PBS. (a) Four weeks and (b) 8 weeks later, mice were not fed for 4 h and were injected with glucose, and blood glucose levels were measured (–10 per group). The area under the curve measured at (c) 4 weeks and (d) 8 weeks. Untreated diabetic db/db mice and pair-fed diabetic db/db mice served as controls. , , and compared with PBS-treated mice; , , and compared with the pair-fed group;   pair-fed mice compared with PBS-treated mice; , compared with untreated mice.

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