Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic db/db Mice by Inhibition of Hepatic Gluconeogenesis

Figure 3

SA treatment did not improve insulin sensitivity in diabetic db/db mice. Diabetic db/db mice were orally intubated with SA (10 mg kg⁻¹ body weight/day) or PBS. (a) Four weeks and (b) 8 weeks later, insulin was injected and blood glucose levels were measured (–10 per group). Data are expressed as a percentage of the initial blood glucose level before insulin injection. The area under the curve measured at (c) 4 weeks and (d) 8 weeks. Untreated diabetic db/db mice and pair-fed diabetic db/db mice served as controls.

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