Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic db/db Mice by Inhibition of Hepatic Gluconeogenesis

Figure 7

Increase of AgRP gene expression in hypothalamus of SA-treated db/db mice. Diabetic db/db mice were orally intubated with SA (10 mg kg⁻¹ body weight/day) or PBS. Eight weeks later, the hypothalamus was removed, and the expression of (a) AgRP, (b) POMC, and (c) MC4R mRNA was analyzed by RT-qPCR and normalized by cyclophilin expression. The fold change was calculated as a ratio of the expression level in PBS-treated diabetic db/db mice. , compared with PBS-treated db/db mice (–10/group).

(a)

(b)

(c)