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Journal of Diabetes Research
Volume 2014, Article ID 978143, 6 pages
Research Article

Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

1Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey
2Department of Biochemistry, Namik Kemal University, Turkey
3Department of Diabetic Patient Education and Care Policlinic, Gaziosmanpasa Taksim Education and Research Hospital, Turkey

Received 1 November 2014; Revised 8 December 2014; Accepted 9 December 2014; Published 22 December 2014

Academic Editor: Mark A. Yorek

Copyright © 2014 Banu Boyuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aim. Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM). Materials and Methods. The study included 88 T2DM patients and 33 healthy controls. Fasting blood samples were obtained from the patients and the control group. The serum levels of BDNF were measured with an ELISA kit. The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients. Results. The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 ± 107.32 pg/mL versus 130.84 ± 59.81 pg/mL; ). They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (; ), the triglyceride level (; ), and white blood cell (WBC) count (; ). In logistic regression analysis, age (), body mass index (BMI) (), C-reactive protein (CRP) (), and BDNF () were independently associated with T2DM. In ROC curve analysis, BDNF cut-off was 137. Conclusion. The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off value of 137. The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation.