Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance

Table 1

Effect of myriocin treatment (for 7 days) and high fat diet feeding (for 5 weeks) on body weight, chow diet consumption, fasting serum glucose level, fasting serum insulin level, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index, and serum FFA level [ (per group) = 8].

	C	M	HFD	HFD + M
Initial body weight (g)	237.5 ± 10.7	209.9 ± 9.2	59.625 ± 5.37	59.75 ± 5.06
Final body weight (g)	315.6 ± 17.0	238.0 ± 17.4	375.4 ± 18.1	278.5 ± 14.3
Chow consumption (g)	20.9 ± 3.6	19.3 ± 2.77	13.25 ± 1.39	13.63 ± 1.19
Glucose level (mg/dL)	101.3 ± 6.4	94.8 ± 7.5	164.5 ± 12.4	91.3 ± 11.6^†
Insulin level (U/mL)	4.6 ± 0.6	4.5 ± 0.6	55.7 ± 5.7	34.8 ± 2.6
HOMA-IR	1.6 ± 1.1	1.4 ± 0.6	20.0 ± 2.5	6.6 ± 1.3
FFA level (mol/L)	88.6 ± 10.4	195.9 ± 22.6	152.4 ± 10.1	365.5 ± 17.6

C: control group. M: group treated with myriocin. HFD: group fed with high fat diet. HFD + M: group fed with high fat diet and treated with myriocin. FFA: free fatty acids. Results are expressed as means ± SD.
compared with C group.
^† compared with HFD group.