Research Article

Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits

Table 1

Pharmacokinetic parameters obtained for glucose after the administration of an oral 3 g glucose load in the 6 groups after study. Group 1: control standard; group 2: oral metformin; group 3: oral metformin with Plantago ovata husk; group 4: control supplemented; group 5: oral metformin with supplemented chow; group 6: oral metformin with Plantago ovata husk with supplemented chow.

Standard chowSupplemented chow
GroupGroup 1Group 2Group 3Group 4Group 5Group 6

(mg/dL)552.5 ± 38.93533.7 ± 75.11578.2 ± 25.48508.9 ± 106.8493.4 ± 87.92513.7 ± 72.53
(min)130.0 ± 24.49110.0 ± 45.1790.0 ± 32.8680.00 ± 30.9865.0 ± 58.2265.0 ± 29.49
AUC (mg⋅min/dL)88330.1 ± 5483.583147.1 ± 12585.596425.1 ± 5524.284983.6 ± 21498.877194.4 ± 17568.284637.1 ± 10774.4