Suppressive Effect of Insulin on the Gene Expression and Plasma Concentrations of Mediators of Asthmatic Inflammation

Table 1

Change in inflammatory and oxidative stress mediators in MNC and serum following 2 U/hr insulin/dextrose infusion (insulin), dextrose alone (dextrose), or saline alone (saline) in obese T2DM for 4 hours. Data are presented as mean ± SE. by one-way RMANOVA (compared to baseline as absolute value and percent change); by two-way RMANOVA compared to control groups (as percent change from baseline).

	Group	0 h	2 h	4 h	6 h
Glucose (mg/dL)	Saline	134 ± 16	118 ± 14	112 ± 12	107 ± 11^*
	Dextrose	133 ± 14	135 ± 11	125 ± 11	110 ± 10^*
	Insulin	122 ± 15	114 ± 12	111 ± 10	109 ± 12^*
Insulin (U/mL)	Saline	24.1 ± 4	25.4 ± 6	21.8 ± 5	22.4 ± 6
	Dextrose	27.6 ± 5	25.4 ± 6	22.9 ± 6	23.5 ± 7
	Insulin	20.1 ± 3	50.5 ± 8^*#	43.8 ± 9^*#	24.8 ± 4
MNC ROS generation (%)	Saline	100	97 ± 8	102 ± 7	96 ± 9
	Dextrose	100	109 ± 7	112 ± 8	104 ± 7
	Insulin	100	95 ± 6	82 ± 5^*#	112 ± 9
MCP-1 (ng/mL)	Saline	275 ± 36	277 ± 38	269 ± 34	262 ± 34
	Dextrose	256 ± 38	262 ± 33	258 ± 31	269 ± 36
	Insulin	270 ± 40	233 ± 30^*	225 ± 29^*#	282 ± 41
MMP-9 (ng/mL)	Saline	354 ± 58	342 ± 49	339 ± 55	341 ± 47
	Dextrose	327 ± 63	312 ± 55	313 ± 57	315 ± 48
	Insulin	367 ± 58	338 ± 47	321 ± 31^*#	352 ± 44