Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats

Figure 1

Effect of metformin on weight and indices of serum biochemical in rats. Different doses of metformin were administered to rats for 8 weeks. BG, HbA1c, and INS (a); TG, LDL-C, and TC (b); weight (c); and serum BUN (d) levels were determined as described in Materials and Methods. NC: normal rats; DM: HFD-STZ rats; M1: HFD-STZ + metformin (150 mg/kg per day) treatment rats; M2: HFD-STZ + metformin (300 mg/kg per day) treatment rats; M3: HFD-STZ + metformin (500 mg/kg per day) treatment rats. Data are expressed as mean ± SD. , versus NC group; , versus DM group; , versus M1 group. Games-Howell test was adopted to compare the level of weight and TC.

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