Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats

Figure 3

Effect of metformin on the renal histopathological changes in rats. The histopathological changes of renal tissue under electron microscopy among five groups (×10 000) (a); GBMT (b); FRFP (c). NC: normal rats; DM: HFD-STZ rats; M1: HFD-STZ + metformin (150 mg/kg per day) treatment rats; M2: HFD-STZ + metformin (300 mg/kg per day) treatment rats; M3: HFD-STZ + metformin (500 mg/kg per day) treatment rats. All values were expressed in mean ± SD. , versus NC group; , versus DM group; , versus M1 group.

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(b)

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