Journal of Diabetes Research / 2015 / Article / Tab 1

Research Article

Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing

Table 1

Wound closure data in diabetic and nondiabetic (control) rats, each treated with topical rhCTGF or PBS alone.

Wound closure (% of initial wound size)
GroupDay 1Day 3Day 7Day 10Day 14

C + PBS alone85.7 ± 1.557.7 ± 2.125.2 ± 0.9*18.0 ± 0.613.0 ± 0.4
DM + PBS alone92.8 ± 1.661.7 ± 1.731.0 ± 1.120.7 ± 0.815.9 ± 0.5
C + CTGF 81.7 ± 1.4*52.2 ± 1.8*25.6 ± 0.9*16.5 ± 0.413.2 ± 0.3*
DM + CTGF85.4 ± 1.457.5 ± 2.228.4 ± 1.2*16.1 ± 0.7*13.6 ± 0.4*

Results are shown as mean ± SEM. * versus the same day diabetic wounds + PBS (DM + PBS alone), by ANOVA. The main finding was that ulcer area was significantly reduced on days 7, 10, and 14 in the CTGF treated diabetic group (D + CTGF) compared with the non-rhCTGF treated diabetic group (D + PBS alone).

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