Proteases and Protease Inhibitors of Urinary Extracellular Vesicles in Diabetic Nephropathy

Table 2

Protease inhibitor array, coordinates, features, and changing fold.

Coordinates	Protein name	Uniprot number	Gene name	Vesiclepedia	Normo	Micro	Macro
A3, A4	Protease Nexin II	P05067	APP	√	−1.75	−1.37	−1.90
A5, A6	Cystatin A	P01040	CSTA	√	−1.35	−1.62	−1.73
A7, A8	Cystatin B	P04080	CSTB	√	3.74	2.39	2.91
A11, A12	Cystatin E/M	Q15828	CST6	√	−2.75	−1.71	−2.36
A13, A14	EMMPRIN/CD147	P35613	BSG	√	−2.05	−2.27	−3.08
A15, A16	Fetuin B	Q9UGM5	FETUB	X	1.11	1.44	1.68
B3, B4	HAI-2	O43291	SPINT2	√^‡	−2.38	−2.43	−2.82
B5, B6	HE4/WFDC2	Q14508	WAP 5	√^‡	−2.44	−1.81	−1.99
B9, B10	Lipocalin-1	P31025	LCN1	√	−1.62	−1.30	−1.47
B11, B12	Lipocalin-2/NGAL	P80188	LCN2	√	2.72	−1.30	−1.61
B17, B18	Serpin A8	P01019	AGT	√	−1.19	1.79	1.50
C7, C8	Serpin B5	P36952	SERPINB5	√	−1.03	1.06	2.67
C9, C10	Serpin B6	P35237	SERPINB6	√	−1.43	−1.57	−1.81
C15, C16	Serpin F1	P36955	SERPINEF1	√	−1.23	1.69	2.36
D5, D6	TFPI	P10646	TFPI	√	−1.44	−1.46	−1.54
D7, D8	TFPI-2	P48307	TFPI2	X	−1.31	−1.44	−1.61
D9, D10	TIMP-1	P01033	TIMP1	√	−1.31	−1.14	−1.57
D11, D12	TIMP-2	P16035	TIMP2	√	1.29	−1.47	−1.86
D17, D18	Elafin	P19957	PI3	X	4.62	2.84	1.15

Reported in vesiclepedia database as mRNA.