Association of 2184AG Polymorphism in the RAGE Gene with Diabetic Nephropathy in Chinese Patients with Type 2 Diabetes
Table 1
Clinical and laboratory characteristics of patients with type 2 diabetes with and without diabetic nephropathy.
Without diabetic nephropathy
With diabetic nephropathy
486
382
—
Sex (male/female)
248/238
217/165
0.09
Age (years)
60.8 ± 11.7
61.6 ± 11.0
0.101
Age at diagnosis of diabetes (years)
51.2 ± 12.2
53.1 ± 11.8
0.030
Known duration of diabetes (years)
8.2 (5.6–12.1)
9.3 (3.7–13.6)
0.019
Smoking (%)
56 (11.5)
49 (12.8)
0.558
Body mass index (kg/m2)
23.7 ± 3.2
23.4 ± 3.0
0.756
Hypertension (%)
144 (29.6)
225 (58.9)
<0.001
Systolic blood pressure (mmHg)
131.0 ± 17.5
141.4 ± 21.0
<0.001
Diastolic blood pressure (mmHg)
80.9 ± 11.3
82.9 ± 11.9
0.035
HbA1c (%)
8.58 ± 2.26
8.51 ± 2.24
0.726
Fasting blood glucose (mmol/L)
8.61 ± 3.32
8.59 ± 2.89
0.653
Total cholesterol (mmol/L)
4.47 ± 1.31
4.45 ± 1.29
0.695
Triglycerides (mmol/L)
1.36 (0.84–1.93)
1.39 (0.87–2.16)
0.630
LDL-cholesterol (mmol/L)
3.06 ± 0.79
3.69 ± 0.81
0.009
HDL-cholesterol (mmol/L)
1.15 (0.89–1.32)
1.10 (0.83–1.29)
0.639
Retinopathy (%)
100 (20.6)
244 (63.7)
<0.001
Hypoglycemic treatments
OHA (%)
185 (38.1)
101 (26.4)
<0.001
Insulin (%)
130 (26.7)
165 (43.2)
Insulin + OHA (%)
171 (35.2)
116 (30.4)
Data are means ± SD, medians (interquartile range), or (%). values were obtained by an unpaired Student’s -test analysis or test, as appropriate. OHA, oral hyperglycemic agent.
