Metformin Treatment in Type 2 Diabetes in Pregnancy: An Active Controlled, Parallel-Group, Randomized, Open Label Study in Patients with Type 2 Diabetes in Pregnancy
Table 1
Baseline demographic and maternal characteristics in treatment groups ().
Parameters
Group
Mean ± SD
valuea
valueb
valuec
Age (years)
Metformin alone
31.75 ± 2.82
0.05*
Metformin + insulin
34.09 ± 3.51
0.07
Insulin alone
33.73 ± 2.95
0.956
Parity
Metformin alone
2.56 ± 1.15
0.550
Metformin + insulin
2.83 ± 1.18
0.038*
Insulin alone
3.18 ± 1.15
0.025*
BMI-early pregnancy (kg/m2)
Metformin alone
28.25 ± 1.98
<0.01*
Metformin + insulin
33.59 ± 3.97
<0.01*
Insulin alone
32.96 ± 4.04
0.171
BMI-late pregnancy (kg/m2)
Metformin alone
32.47 ± 2.19
<0.01*
Metformin + insulin
38.09 ± 4.26
<0.01*
Insulin alone
38.01 ± 4.18
0.714
Total weight gain in pregnancy (Kg)
Metformin alone
10.38 ± 1.20
0.868
Metformin + insulin
10.52 ± 1.14
<0.01*
Insulin alone
11.80 ± 0.86
<0.01*
FBS at starting treatment (mg/dl)
Metformin alone
138.06 ± 45.58
0.304
Metformin + insulin
144.14 ± 29.64
0.877
Insulin alone
139.85 ± 29.43
0.155
RBS at starting treatment (mg/dl)
Metformin alone
192.88 ± 25.56
0.326
Metformin + insulin
195.03 ± 21.69
0.041*
Insulin alone
201.21 ± 16.78
0.158
Mean FBS throughout pregnancy (mg/dl)
Metformin alone
97.87 ± 3.83
0.586
Metformin + insulin
97.50 ± 3.35
0.672
Insulin alone
97.55 ± 3.29
0.962
Mean RBS throughout pregnancy (mg/dl)
Metformin alone
136.79 ± 5.34
0.176
Metformin + insulin
134.79 ± 5.69
0.237
Insulin alone
135.31 ± 4.64
0.944
value calculated by using independent -testMann-Whitney test. aComparison between means of metformin alone and metformin + insulin groups. bComparison between means of metformin alone and insulin alone. cComparison between means of metformin + insulin and insulin alone. *Significant level ≤0.05. FBS: fasting blood glucose. RBS: random blood glucose.
