Metformin Treatment in Type 2 Diabetes in Pregnancy: An Active Controlled, Parallel-Group, Randomized, Open Label Study in Patients with Type 2 Diabetes in Pregnancy
Table 4
Pharmacotherapeutic characteristics in treatment groups ().
Parameters
Group
Mean ± SD
valuea
valueb
valuec
Dose of drug
Metformin: mean dose grams/day
Metformin alone
2.21 ± 0.63
0.665
Metformin + insulin
2.29 ± 0.64
—
Insulin alone
—
—
Insulin: mean dose units/day
Metformin alone
—
—
Metformin + insulin
23.69 ± 4.61
—
Insulin alone
77.62 ± 12.69
<0.01*
Mean gestational age when insulin started (weeks)
Metformin alone
—
—
Metformin + insulin
26.58 ± 3.85
—
Insulin alone
9.55 ± 5.21
<0.01*
Financial benefits
Total cost throughout pregnancy (PKR)
Metformin alone
448 ± 131
<0.01*
Metformin + insulin
5004 ± 754
<0.01*
Insulin alone
10976 ± 6339
<0.01*
Total cost throughout pregnancy (USD)
Metformin alone
4.39 ± 1.01
<0.01*
Metformin + insulin
49.05 ± 7.39
<0.01*
Insulin alone
107.60 ± 62.14
<0.01*
value calculated by using Mann-Whitney test. aComparison between means of metformin alone and metformin + insulin groups. bComparison between means of metformin alone and insulin alone groups. cComparison between means of metformin + insulin and insulin alone groups. *Significant level ≤0.05. PKR: Pakistani rupee. USD: US dollar.