Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats

Figure 2

Effect of TGT on E-cadherin and α-SMA localization and expression in diabetic rat kidney by immunohistochemistry and western blot. (a) Immunostaining of E-cadherin and α-SMA was shown for different groups. (b) Representative western blotting analysis of E-cadherin and α-SMA was shown for different groups. (c-d) Densitometric results of E-cadherin and α-SMA, as determined by western blot. NC: normal control; DM: diabetic rats without drug treatment; TL: low-dose TGT (1 mg/kg/day); TM: medium-dose TGT (3 mg/kg/day); TH: high-dose TGT (6 mg/kg/day). versus NC group, versus DM group, versus TL group, and versus TM group.

(a)

(b)

(c)

(d)