Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats

Table 1

Physical and biochemical parameters of the rats in different groups (mean ± SD).

	NC ()	DM ()	TL ()	TM ()	TH ()
Blood glucose (mmol/L)	6.0 ± 0.2	28.2 ± 3.0^a	25.8 ± 6.9^a	27.6 ± 5.7^a	29.0 ± 3.1^a
TC (mmol/L)	3.7 ± 1.2	6.5 ± 1.9^a	6.6 ± 2.1^a	6.4 ± 2.2^a	6.2 ± 2.0^a
TG (mmol/L)	1.5 ± 1.2	4.1 ± 1.8^a	4.0 ± 2.2^a	3.7 ± 1.8^a	3.8 ± 1.4^a
ALT (mmol/L)	49.7 ± 7.5	55.1 ± 5.1	53.8 ± 10.9	54.9 ± 9.7	54.2 ± 8.9
AST (mmol/L)	75.1 ± 7.1	79.4 ± 6.4	76.8 ± 7.5	79.5 ± 5.9	82.2 ± 6.3
BUN (mmol/L)	6.9 ± 2.0	6.7 ± 1.6	6.9 ± 1.3	7.0 ± 1.9	6.8 ± 1.2
Scr (mmol/L)	62.8 ± 8.4	61.3 ± 7.3	62.8 ± 9.5	61.1 ± 8.1	61.5 ± 7.8
24-h urine protein (mg/24 h)	45.7 ± 14.5	253.7 ± 33.0^a	183.5 ± 28.7^a,b	123.8 ± 24.8^a,b,c	119.0 ± 22.0^a,b,c
NAG	12.3 ± 4.1	59.5 ± 9.3^a	41.7 ± 8.9^a,b	32.9 ± 7.5^a,b,c	29.4 ± 7.2^a,b,c
KW/BW	3.21 ± 0.18	6.78 ± 0.48^a	5.90 ± 0.55^a,b	4.89 ± 0.3^a,b,c	4.55 ± 0.38^a,b,c

TC: total cholesterol; TG: total triglycerides; ALT: alanine transaminase; AST: aspartate transaminase; BUN: blood urea nitrogen; Scr: serum creatinine; NC: normal control; DM: diabetic rats without drug treatment; TL: low-dose TGT (1 mg/kg/day); TM: medium-dose TGT (3 mg/kg/day); TH: high-dose TGT (6 mg/kg/day). versus NC group, versus DM group, and versus TL group.