Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats
Table 1
Physical and biochemical parameters of the rats in different groups (mean ± SD).
NC ()
DM ()
TL ()
TM ()
TH ()
Blood glucose (mmol/L)
6.0 ± 0.2
28.2 ± 3.0a
25.8 ± 6.9a
27.6 ± 5.7a
29.0 ± 3.1a
TC (mmol/L)
3.7 ± 1.2
6.5 ± 1.9a
6.6 ± 2.1a
6.4 ± 2.2a
6.2 ± 2.0a
TG (mmol/L)
1.5 ± 1.2
4.1 ± 1.8a
4.0 ± 2.2a
3.7 ± 1.8a
3.8 ± 1.4a
ALT (mmol/L)
49.7 ± 7.5
55.1 ± 5.1
53.8 ± 10.9
54.9 ± 9.7
54.2 ± 8.9
AST (mmol/L)
75.1 ± 7.1
79.4 ± 6.4
76.8 ± 7.5
79.5 ± 5.9
82.2 ± 6.3
BUN (mmol/L)
6.9 ± 2.0
6.7 ± 1.6
6.9 ± 1.3
7.0 ± 1.9
6.8 ± 1.2
Scr (mmol/L)
62.8 ± 8.4
61.3 ± 7.3
62.8 ± 9.5
61.1 ± 8.1
61.5 ± 7.8
24-h urine protein (mg/24 h)
45.7 ± 14.5
253.7 ± 33.0a
183.5 ± 28.7a,b
123.8 ± 24.8a,b,c
119.0 ± 22.0a,b,c
NAG
12.3 ± 4.1
59.5 ± 9.3a
41.7 ± 8.9a,b
32.9 ± 7.5a,b,c
29.4 ± 7.2a,b,c
KW/BW
3.21 ± 0.18
6.78 ± 0.48a
5.90 ± 0.55a,b
4.89 ± 0.3a,b,c
4.55 ± 0.38a,b,c
TC: total cholesterol; TG: total triglycerides; ALT: alanine transaminase; AST: aspartate transaminase; BUN: blood urea nitrogen; Scr: serum creatinine; NC: normal control; DM: diabetic rats without drug treatment; TL: low-dose TGT (1 mg/kg/day); TM: medium-dose TGT (3 mg/kg/day); TH: high-dose TGT (6 mg/kg/day). versus NC group, versus DM group, and versus TL group.