Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels

Table 3

Haplotypes and intima media thickness of common carotid arteries.

Haplotype	Frequencies (%)	IMT (mm)
1111	0.166	0.097 (0.060–0.135)	n.s.
1112	0.402	0.103 (0.065–0.141)	Reference
1121	0.027	0.111 (0.069–0.153)	n.s.
1221	0.013	0.101 (0.044–0.158)	n.s.
2112	0.027	0.105 (0.063–0.147)	n.s.
2221	0.322	0.092 (0.056–0.129)	0.0265

For haplotype designation, 1 or 2 refers to the major or minor alleles, respectively, in the following order: rs7578326, rs2943634, rs2943641, and rs2713538. (943 men, 599 women); data are expected as means (95% CI) of average IMTs of common carotid arteries, adjusted for age, sex, BMI, hypertension status, smoking status, use of lipid lowering drugs, LDL cholesterol, and CRP. Global haplotype effect n.s.; IMT, intima media thickness; n.s., not significant.