Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels

Table 4

Haplotypes and LOC646736 and IRS1 transcript levels in skeletal muscle.

Haplotype	Frequencies (%)	LOC646736		IRS1
		Log transcript level (AU)		Log transcript level (AU)
1111	0.164	0.258 (−0.006–0.522)	n.s.	0.574 (0.327–0.821)	n.s.
1112	0.411	0.257 (−0.006–0.522)	Reference	0.534 (0.345–0.725)	Reference
1121	0.022	0.170 (−0.385–0.726)	n.s.	0.434 (−0.240–1.109)	n.s.
1221	0.017	0.221 (−1.747–2.189)	n.s.	0.480 (−1.283–2.244)	n.s.
2112	0.028	0.484 (0.005–0.969)	n.s.	0.438 (−0.012–0.889)	n.s.
2221	0.336	0.418 (0.113–0.724)	0.0096	0.625 (0.369–0.881)	0.1928

For haplotype designation, 1 or 2 refers to the major or minor alleles, respectively, in the following order: rs7578326, rs2943634, rs2943641, and rs2713538; data are means (95% CI) in arbitrary units (AU) of 92 subjects, adjusted for age, sex, and BMI; global haplotype effect for LOC646736 and ; n.s., not significant. Transcript quantification of LOC646736 (with primers targeting exons 6 and 7) and IRS1 are normalized for RPL0.