Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

Table 1

Summary of clinical trials comparing the effect of intensive and conventional glycemic control on the prognosis of diabetic complications in type 1 and type 2 diabetic patients. Related to microalbuminuria and proteinuria levels.

Clinical trial	Type of diabetes	Number of cases	Duration of follow-up (years)	Effect of intensive versus conventional glycemic control on diabetic complications
				Retinopathy	Neuropathy	Nephropathy	Cardiovascular defects
SDIS	T1D	96	5	+	+	+	NA
DCCT	T1D	1441	6.5	+	+	+	=
DCCT/EDIC	T1D	1375	8	NA	NA	+	+
DCCT/EDIC	T1D	1214	18	+	NA	NA	NA
KPCT	T2D	110	6	+	+	+	NA
STENO2	T2D	160	7.8	+	+	+	+
UKPDS	T2D	3867	10	+	NA	+	=
VADT	T2D	1791	5.6	=	=	=	=
ADVANCE	T2D	11140	5	=	NA	+	=
ACCORD	T2D	10251	3.5	NA	NA	NA	−

+, benefit; =, no change; −, harm; NA, not assessed.