Diabetes-Resistant NOR Mice Are More Severely Affected by Streptozotocin Compared to the Diabetes-Prone NOD Mice: Correlations with Liver and Kidney GLUT2 Expressions

Figure 1

Changes in pancreatic islet content following STZ treatment. Representative images showing pancreatic islet contents in NOD (upper panel) and NOR mice (lower panel) before and after STZ application. Pancreatic tissues were stained with anti-insulin (green) and anti-glucagon (red) antibodies, and counterstaining was done with DAPI nuclear stain. Pictures represent islet images of pancreatic tissues isolated from animals sacrificed on day 0 (before STZ injection) and on days 1, 2, 4, 7, 11, and 14, after 150 mg/kg STZ injection ( for each time point).