Diabetes-Resistant NOR Mice Are More Severely Affected by Streptozotocin Compared to the Diabetes-Prone NOD Mice: Correlations with Liver and Kidney GLUT2 Expressions

Figure 3

GLUT2 expression levels in the pancreatic beta cells of NOD and NOR mice. (a) Representative images of dual stainings for insulin (red) and GLUT2 expressions (green) in the presence of DAPI counter-staining (blue), before STZ application (day 0). (b) Mean fluorescence intensities for GLUT2 expression in NOD (lighter bars) and NOR islet beta cells (darker bars) on days 0, 1, 2, 4, 7, 11, and 14 of STZ injection. Five to twenty islets per animal were analysed via ImageJ program (/group). , significance between values observed in NOD versus NOR mice; , significance between values detected in NOR mice before STZ injection and at different time points after treatment (Student’s -test).

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