Research Article
Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes
Table 3
Univariate correlations of clot permeability (
, 10
−9 cm
2) and clot lysis time (CLT, min).
| | | , | CLT | | CLT1 |
|
HbA1c, % | | −0.30 | 0.14 | | | | 0.0002 | 0.10 | | |
| DM duration | | −0.32 | 0.14 | | | | 0.0001 | 0.09 | | |
| Nitrotyrosine, nM/mL | | −0.44 | 0.19 | −0.47 | 0.14 | | <0.001 | 0.02 | <0.001 | 0.08 |
| AGE, U/mL | | −0.20 | 0.107 | −0.17 | −0.02 | | 0.01 | 0.20 | 0.05 | 0.82 |
| sRAGE, ng/mL | | −0.27 | 0.13 | −0.26 | 0.05 | | 0.001 | 0.11 | 0.001 | 0.53 |
| , pg/mL | | −0.22 | 0.13 | −0.25 | 0.11 | | 0.007 | 0.10 | 0.003 | 0.19 |
| oxLDL, ng/mL | | −0.33 | 0.48 | −0.21 | 0.41 | | 0.0001 | <0.0001 | 0.01 | <0.0001 |
| Glucose, mmol/L | | −0.14 | 0.20 | | | | 0.07 | 0.02 | | |
|
|
after adjustment for fibrinogen, DM duration time, and HbA1c. Abbreviations: see Tables 1 and 2.
|