Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats
Table 3
Isolated papillary muscle data at basal condition and after positive inotropic stimulation.
C-Sed ()
C-Ex ()
DM-Sed ()
DM-Ex ()
DT (g/mm2)
8.57 ± 2.13
7.13 ± 1.82
7.35 ± 1.13
7.23 ± 1.53
TPT (ms)
169 ± 15
175 ± 15
183 ± 16
176 ± 16
Basal
+dT/dt (g/mm²/s)
99.9 ± 29.1
78.9 ± 17.0*
78.9 ± 16.8*
76.6 ± 17.4
−dT/dt (g/mm²/s)
32.2 (29.8–42.6)
29.8 (25.3–37.0)
27.1 (23.8–33.6)
28.2 (24.2–35.7)
RT (g/mm2)
1.02 (0.81–1.09)
0.90 (0.66–1.04)
0.88 (0.75–0.97)
0.88 (0.70–0.97)
DT (g/mm2)
10.56 ± 2.37
8.68 ± 2.59
8.45 ± 1.56*
8.45 ± 1.96
TPT (ms)
160 (160–180)
180 (170–193)
180(170–190)
170 (170–193)
PP30
+dT/dt (g/mm²/s)
122 ± 32.9
94.5 ± 25.6*
90.8 ± 21.1*
88.8 ± 21.2
−dT/dt (g/mm²/s)
39.1 ± 12.2
34.1 ± 9.14
29.4 ± 6.88*
30.4 ± 7.14
RT (g/mm2)
0.98 (0.84–1.09)
0.91 (0.56–1.04)
0.89 (0.75–0.94)
0.89 (0.69–1.05)
DT (g/mm2)
8.97 (8.35–10.6)
8.80 (7.56–12.1)
7.73 (6.58–9.07)
8.97 (6.20–11.3)
TPT (ms)
160 (160–180)
170 (170–180)
195 (170–200)*
170 (160–180)
2.5 mM
+dT/dt (g/mm²/s)
119 ± 28.4
108 ± 36.0
90.3 ± 22.9
84.6 ± 37.2
−dT/dt (g/mm²/s)
36.2 (32.4–46.5)
38.3 (31.4–55.8)
32.0 (25.7–38.6)
24.6 (20.8–39.9)
RT (g/mm2)
0.89 ± 0.30
0.72 ± 0.34
0.68 ± 0.19
0.76 ± 0.35
DT (g/mm2)
7.80 (7.08–9.86)
6.71 (5.53–9.48)
7.14 (5.95–8.46)
6.91 (6.45–8.81)
TPT (ms)
149 ± 13
160 ± 17
167 ± 9*
167 ± 14
10−6 M Iso
+dT/dt (g/mm²/s)
117 ± 25.6
99.5 ± 25.1
92.7 ± 22.1*
91.1 ± 17.7
−dT/dt (g/mm²/s)
58.1 ± 11.5
55.3 ± 13.6
44.4 ± 12.4*
44.3 ± 9.67#
RT (g/mm2)
0.85 ± 0.32
0.60 ± 0.31
0.65 ± 0.18
0.73 ± 0.34
Values are mean ± SD or median and 25th and 75th percentiles. C-Sed: sedentary control group; C-Ex: exercised control group; DM-Sed: sedentary diabetic group; DM-Ex: exercised diabetic group; DT: peak of developed tension; TPT: time to peak of tension; +dT/dt: maximum rate of tension development; −dT/dt: maximum rate of tension decline; RT: resting tension. Basal: isometric contraction with 1.25 mM extracellular calcium concentration; PP30: postrest contraction of 30 s; 2.5 mM : isometric contraction with 2.5 mM extracellular calcium concentration; 10−6 M Iso: isometric contraction with 10−6 M isoproterenol added to the nutrient solution. ANOVA and Bonferroni or Kruskal-Wallis and Dunn; versus C-Sed; versus C-Ex.
