Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats
Maternal and fetal glucose and insulin levels. Glucose was infused into the left uterine artery from gestational day 19 until day 20. (a) Maternal blood glucose was measured in the nonfasted state just prior to infusion on gestational day 19 and just before the conclusion of the infusion on gestational day 20. The euglycemic range (70–130) is highlighted on the figure in grey. by paired -test, dams. (b) Fetal blood glucose was measured just before the conclusion of the infusion for right-sided (i.e., control, “con”) and left-sided (i.e., hyperglycemia infused, “HG”) fetuses. by paired -test, dams, 26-27 fetuses. (c) Fetal serum insulin just before the conclusion of the infusion. by -test, dams, 10–12 fetuses.