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Journal of Diabetes Research
Volume 2015, Article ID 483238, 10 pages
http://dx.doi.org/10.1155/2015/483238
Research Article

Sex-Differences in Renal Expression of Selected Transporters and Transcription Factors in Lean and Obese Zucker Spontaneously Hypertensive Fatty Rats

1Institute for Cardiovascular Physiology (Physiology I), Faculty of Medicine, Goethe-University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany
2Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, 83391 Bratislava, Slovakia
3Institute for Systemic Physiology and Pathophysiology, University Medical Center Göttingen, Humboldtallee 23, 37073 Göttingen, Germany

Received 1 October 2014; Revised 22 December 2014; Accepted 23 December 2014

Academic Editor: Bernard Portha

Copyright © 2015 Andrea Babelova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary figure 1. Sex-different expression of renal genes in lean (le) and obese (ob) ZSF1 rats. Gene expressions were analyzed using TaqMan® real-time PCR. DCt = Hprt1-gene of interest and DDCt = δCtle-female – δCtle-male or DDCt = δCtob-female – δCtob-male, n = 6–8. a: P <0.05, P <0.01, and c: P <0.001, for the comparison of δCt values for each gene. Values above the horizontal line of unity represent female-dominantly expressed genes, those below the line of unity genes with higher expression in males.

Supplementary figure 2. Renal gene expression in lean (le) and obese (ob) ZSF1 rats. Gene expressions were analyzed using TaqMan® real-time PCR. DCt = Hprt1 - gene of interest and DDCt = δCtle-female - δCtob-female or DDCt = δCtle-male – δCtob-male, n =  6–8. a: P < 0.05, b: P <0.01, and c: P <0.001, for the comparison of δCt values for each gene. Values above the horizontal line of unity represent genes with higher expression in lean as compared to obese rats.

  1. Supplementary Material