Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2015, Article ID 507245, 8 pages
http://dx.doi.org/10.1155/2015/507245
Research Article

Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
2Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
3Department of Hematology, Endocrinology and Metabolism, School of Medicine, Niigata University, Niigata, Niigata 951-8510, Japan
4Division of Endocrinology and Metabolism, Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ami, Ibaraki 300-0331, Japan
5International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

Received 9 December 2014; Revised 8 March 2015; Accepted 10 March 2015

Academic Editor: Shi Fang Yan

Copyright © 2015 Kazuya Fujihara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. International Diabetes Federation, IDF Diabetes Atlas, 6th edition, 2014, http://www.idf.org/diabetesatlas/.
  2. E. S. Ford, “Trends in the risk for coronary heart disease among adults with diagnosed diabetes in the U.S.: findings from the National Health and Nutrition Examination Survey, 1999–2008,” Diabetes Care, vol. 34, no. 6, pp. 1337–1343, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. E. A. Hulten, S. Carbonaro, S. P. Petrillo, J. D. Mitchell, and T. C. Villines, “Prognostic value of cardiac computed tomography angiography: a systematic review and meta-analysis,” Journal of the American College of Cardiology, vol. 57, no. 10, pp. 1237–1247, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. J. S. Rana, A. Dunning, S. Achenbach et al., “Differences in prevalence, extent, severity, and prognosis of coronary artery disease among patients with and without diabetes undergoing coronary computed tomography angiography: results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes): an InteRnational Multicenter Registry,” Diabetes Care, vol. 35, no. 8, pp. 1787–1794, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. A. N. Orekhov, Y. V. Bobryshev, I. A. Sobenin, A. A. Melnichenko, and D. A. Chistiakov, “Modified low density lipoprotein and lipoprotein-containing circulating immune complexes as diagnostic and prognostic biomarkers of atherosclerosis and type 1 diabetes macrovascular disease,” International Journal of Molecular Sciences, vol. 15, no. 7, pp. 12807–12841, 2014. View at Publisher · View at Google Scholar
  6. C.-M. Shen, S. J. T. Mao, G. S. Huang, P.-C. Yang, and R.-M. Chu, “Stimulation of smooth muscle cell proliferation by ox-LDL- and acetyl LDL-induced macrophage-derived foam cells,” Life Sciences, vol. 70, no. 4, pp. 443–452, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Aviram, “Modified forms of low density lipoprotein and atherosclerosis,” Atherosclerosis, vol. 98, no. 1, pp. 1–9, 1993. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Holvoet, A. Mertens, P. Verhamme et al., “Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, no. 5, pp. 844–848, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Tanaga, H. Bujo, M. Inoue et al., “Increased circulating malondialdehyde-modified LDL levels in patients with coronary artery diseases and their association with peak sizes of LDL particles,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 4, pp. 662–666, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Miyazaki, K. Shimada, O. Sato et al., “Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease,” Atherosclerosis, vol. 179, no. 1, pp. 139–145, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Asamiya, A. Yajima, Y. Tsuruta, S. Otsubo, and K. Nitta, “Oxidised LDL/LDL-cholesterol ratio and coronary artery calcification in haemodialysis patients,” Nutrition, Metabolism & Cardiovascular Diseases, vol. 23, no. 7, pp. 619–627, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Hayashi, K. Okumura, H. Matsui et al., “Impact of low-density lipoprotein particle size on carotid intima-media thickness in patients with type 2 diabetes mellitus,” Metabolism, vol. 56, no. 5, pp. 608–613, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Ono, N. Takebe, T. Oda et al., “Association of coronary artery calcification with MDA-LDL-C/LDL-C and urinary 8-isoprostane in Japanese patients with type 2 diabetes,” Internal Medicine, vol. 53, no. 5, pp. 391–396, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Kurobe, K.-I. Aihara, M. Higashida et al., “Ezetimibe monotherapy ameliorates vascular function in patients with hypercholesterolemia through decreasing oxidative stress,” Journal of Atherosclerosis and Thrombosis, vol. 18, no. 12, pp. 1080–1089, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. R. C. Turner, H. Millns, H. A. W. Neil et al., “Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23),” British Medical Journal, vol. 316, no. 7134, pp. 823–828, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Fujihara, H. Suzuki, A. Sato et al., “Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) risk engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes,” Journal of Atherosclerosis and Thrombosis, vol. 21, no. 8, pp. 799–815, 2014. View at Publisher · View at Google Scholar
  17. K. Fujihara, H. Suzuki, A. Sato et al., “Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus,” Journal of Atherosclerosis and Thrombosis, vol. 20, no. 5, pp. 452–464, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Irie, N. Katakami, H. Kaneto et al., “Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery disease,” Atherosclerosis, vol. 221, no. 2, pp. 438–444, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Assmann and A. M. Gotto Jr., “HDL cholesterol and protective factors in atherosclerosis,” Circulation, vol. 109, no. 23, pp. III8–III14, 2004. View at Google Scholar · View at Scopus
  20. E. Ingelsson, E. J. Schaefer, J. H. Contois et al., “Clinical utility of different lipid measures for prediction of coronary heart disease in men and women,” Journal of the American Medical Association, vol. 298, no. 7, pp. 776–785, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Kashiwagi, M. Kasuga, E. Araki et al., “International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values,” Diabetology International, vol. 3, no. 1, pp. 8–10, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Kondo, Y. Muranaka, I. Ohta et al., “Relationship between triglyceride concentrations and LDL size evaluated by malondialdehyde-modified LDL,” Clinical Chemistry, vol. 47, no. 5, pp. 893–900, 2001. View at Google Scholar · View at Scopus
  23. D. L. Tribble, L. G. Holl, P. D. Wood, and R. M. Krauss, “Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size,” Atherosclerosis, vol. 93, no. 3, pp. 189–199, 1992. View at Publisher · View at Google Scholar · View at Scopus
  24. W. B. Kannel, “Risk stratification of dyslipidemia: insights from the Framingham study,” Current Medicinal Chemistry: Cardiovascular & Hematological Agents, vol. 3, no. 3, pp. 187–193, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Enomoto, H. Adachi, Y. Hirai et al., “LDL-C/HDL-C ratio predicts carotid intima-media thickness progression better than HDL-C or LDL-C alone,” Journal of Lipids, vol. 2011, Article ID 549137, 6 pages, 2011. View at Publisher · View at Google Scholar
  26. B. Kinosian, H. Glick, L. Preiss, and K. L. Puder, “Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios,” Journal of Investigative Medicine, vol. 43, no. 5, pp. 443–450, 1995. View at Google Scholar · View at Scopus
  27. A. Hamsten, G. Walldius, A. Szamosi, G. Dahlen, and U. de Faire, “Relationship of angiographically defined coronary artery disease to serum lipoproteins and apolipoproteins in young survivors of myocardial infarction,” Circulation, vol. 73, no. 6, pp. 1097–1110, 1986. View at Publisher · View at Google Scholar · View at Scopus