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Research Article
Journal of Diabetes Research
Volume 2015, Article ID 512959, 3 pages
Letter to the Editor

Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing”

1State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
2Department of Stomatology, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Road, Beijing 100029, China
3Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received 15 June 2015; Accepted 24 August 2015

Academic Editor: Andrea Flex

Copyright © 2015 Hongling Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A recent paper in this journal, presented a novel method by topical application of growth factors in stimulating diabetic cutaneous wound healing that caught our attention. We believe that the experimental method in the article is efficient and creative, but it also has some controversies and shortcomings to be discussed. We noted that the authors used “Tegaderm” as a semiocclusive dressing film and stated that it exerted a “splinting effect” on the wound margins and controlled contraction. Indeed, the “Tegaderm” itself can serve as a dressing film to isolate the wound bed with outside environments while the “splinting effect” is mainly achieved by adding silicone splints around the wound. Considering the unique properties of silicone splints and “Tegaderm,” our experimental group propose an alternative method named “combined-suturing” technique that is not only suturing the silicone splints but also securing the “Tegaderm” around the wound. The specific reasons and operative procedures are explained in detail in this letter.