The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy

Table 2

Electrodiagnostic measures.

	IL-6+ (n = 14)	IL-6− (n = 18)		IL-10+ (n = 5)	IL-10− (n = 27)
Sural nerve
SNAP amplitude (µV)	4.4 ± 6.8, 6.6	9.0 ± 6.9, 10.5	0.033	1.6 ± 3.5, 0.8	8.2 ± 7.2, 10.0	0.032
SNCV (m/s)	47.5 ± 9.8, 47.2	45.3 ± 8.5, 43.8	n.s.	49.0 ± 10.9, 47.0	45.8 ± 8.9, 45.3	n.s.
Common peroneal nerve
CMAP amplitude (mV)	3.2 ± 2.2, 5.3	5.8 ± 3.7, 7.4	0.030	1.0 ± 1.3, 0.5	5.4 ± 3.2, 6.5	0.003
MNCV (m/s)	40.0 ± 6.5, 43.9	42.1 ± 7.0, 44.2	n.s	31.8 ± 5.2, 34.0	42.2 ± 6.1, 44.6	0.009
F-wave minimal latency (ms)	54.7 ± 10.5, 52.0	48.5 ± 6.8, 49.2	n.s.	67.4 ± 13.5, 65.2	49.3 ± 6.5, 49.2	0.042
SSR
Latency (s)	1.4 ± 0.3, 1.3	1.5 ± 0.2, 1.4	n.s.	1.5 ± 0.1, 1.6	1.5 ± 0.3, 1.4	n.s.
Amplitude (µV)	0.9 ± 0.6, 0.8	1.0 ± 0.7, 1.0	n.s.	1.0 ± 0.3, 0.9	1.0 ± 0.7, 1.0	n.s.

Data are presented as mean ± SD, median. p values are from Mann-Whitney test. SNAP: sensory nerve action potential, SNCV: sensory nerve conduction velocity, CMAP: compound muscle action potential, MNCV: motor nerve conduction velocity, and SSR: sympathetic skin response.