Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts

Figure 1

Effect of low glucose (LG) and glucose (G) on myocardial infarct size (IS) and CK-MB release during ischemia reperfusion. Rat hearts were randomly assigned to be perfused with glucose concentration at LG, LG+propofol (LG+P), and LG+propofol+trimetazidine (LG+P+TMZ) or with G, G+propofol (G+P), and G+propofol+trimetazidine (G+P+TMZ). Myocardial IS was measured by TTC staining. Myocardial IS and cardiac CK-MB release were significantly higher in LG than in G (). Propofol significantly reduced IS and CK-MB in G but not in LG. TMZ facilitated propofol induced IS and CK-MB reduction in LG but did not induce further propofol beneficial effects on G. BS20, Re-1, and Re-60 are abbreviations of 20 min after stabilization, 1 and 60 min after reperfusion, respectively. Values are presented as mean ± SEM. per group. versus BS20; versus LG; versus LG+P; versus G.

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