Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2015, Article ID 592028, 10 pages
http://dx.doi.org/10.1155/2015/592028
Research Article

Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts

1Department of Anesthesiology, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou 510130, China
2Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
3Department of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, China
4Department of Anesthesiology, The University of Hong Kong, Hong Kong
5Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

Received 11 January 2015; Accepted 10 February 2015

Academic Editor: Dake Qi

Copyright © 2015 Xinhua Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. T. Mangano, E. L. Layug, A. Wallace, and I. Tateo, “Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery,” The New England Journal of Medicine, vol. 335, no. 23, pp. 1713–1720, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Cook and S. Windecker, “Surgical versus percutaneous revascularization of coronary artery disease in diabetic patients,” Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 23, no. 3, pp. 317–334, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Roffi and F. R. Eberli, “Diabetes and acute coronary syndromes,” Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 23, no. 3, pp. 305–316, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Eapen, G. L. Kalra, N. Merchant, A. Arora, and B. V. Khan, “Metabolic syndrome and cardiovascular disease in South Asians,” Vascular Health and Risk Management, vol. 5, pp. 731–743, 2009. View at Google Scholar · View at Scopus
  5. A. Frank, M. Bonney, S. Bonney, L. Weitzel, M. Koeppen, and T. Eckle, “Myocardial ischemia reperfusion injury: from basic science to clinical bedside,” Seminars in Cardiothoracic and Vascular Anesthesia, vol. 16, no. 3, pp. 123–132, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Wang, H. Zhang, G. Xue et al., “Exercise training preserves ischemic preconditioning in aged rat hearts by restoring the myocardial polyamine pool,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 457429, 14 pages, 2014. View at Publisher · View at Google Scholar
  7. R. Rodrigo, M. Libuy, F. Feliú, and D. Hasson, “Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage,” Disease Markers, vol. 35, no. 6, pp. 773–790, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Niccoli, A. Celestini, C. Calvieri et al., “Patients with microvascular obstruction after primary percutaneous coronary intervention show a gp91phox (NOX2) mediated persistent oxidative stress after reperfusion,” European Heart Journal: Acute Cardiovascular Care, vol. 2, no. 4, pp. 379–388, 2013. View at Publisher · View at Google Scholar
  9. W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk, “Myocardial substrate metabolism in the normal and failing heart,” Physiological Reviews, vol. 85, no. 3, pp. 1093–1129, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. Q. Liu, J. C. Docherty, J. C. T. Rendell, A. S. Clanachan, and G. D. Lopaschuk, “High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation,” Journal of the American College of Cardiology, vol. 39, no. 4, pp. 718–725, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. J. S. Jaswal, W. Keung, W. Wang, J. R. Ussher, and G. D. Lopaschuk, “Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart,” Biochimica et Biophysica Acta, vol. 1813, no. 7, pp. 1333–1350, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. L. C. Heather, K. M. Pates, H. J. Atherton et al., “Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion,” Circulation: Heart Failure, vol. 6, no. 5, pp. 1058–1066, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Liu, S. Lei, X. Gao et al., “PKCbeta inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfuntion in rats with streptozotocin-induced diabetes,” Clinical Science, vol. 122, no. 4, pp. 161–173, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. B. P. C. Kok and D. N. Brindley, “Myocardial fatty acid metabolism and lipotoxicity in the setting of insulin resistance,” Heart Failure Clinics, vol. 8, no. 4, pp. 643–661, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. P. J. Randle, P. B. Garland, C. N. Hales, and E. A. Newsholme, “The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus,” The Lancet, vol. 1, pp. 785–789, 1963. View at Google Scholar
  16. H. L. Lazar, S. R. Chipkin, C. A. Fitzgerald, Y. Bao, H. Cabral, and C. S. Apstein, “Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events,” Circulation, vol. 109, no. 12, pp. 1497–1502, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Malmberg, “Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus,” British Medical Journal, vol. 314, no. 7093, pp. 1512–1515, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Malmberg, A. Norhammar, H. Wedel, and L. Rydén, “Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the diabetes and insulin-glucose infusion in acute myocardial infarction (DIGAMI) study,” Circulation, vol. 99, no. 20, pp. 2626–2632, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Malmberg, L. Rydén, S. Efendic et al., “Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year,” Journal of the American College of Cardiology, vol. 26, no. 1, pp. 57–65, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. G. van den Berghe, P. Wouters, F. Weekers et al., “Intensive insulin therapy in critically ill patients,” The New England Journal of Medicine, vol. 345, no. 19, pp. 1359–1367, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Turner, “Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33),” The Lancet, vol. 352, no. 9131, pp. 837–853, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Rujirojindakul, T. Liabsuetrakul, E. McNeil et al., “Safety and efficacy of intensive intraoperative glycaemic control in cardiopulmonary bypass surgery: a randomised trial,” Acta Anaesthesiologica Scandinavica, vol. 58, no. 5, pp. 588–596, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Vega-López, S. Devaraj, and I. Jialal, “Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease,” Journal of Investigative Medicine, vol. 52, no. 1, pp. 24–32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. I. Vasileiou, T. Xanthos, E. Koudouna et al., “Propofol: a review of its non-anaesthetic effects,” European Journal of Pharmacology, vol. 605, no. 1–3, pp. 1–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. Huang, X. Zhong, M. G. Irwin et al., “Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients,” Clinical Science (Lond), vol. 121, no. 2, pp. 57–69, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. Z. Xia, D. V. Godin, T. K. H. Chang, and D. M. Ansley, “Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-F2t-isoprostane formation,” Canadian Journal of Physiology and Pharmacology, vol. 81, no. 1, pp. 14–21, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Tamaki, T. Oguchi, S. Kashimoto, A. Nonaka, and T. Kumazawa, “Effects of propofol on ischemia and reperfusion in the isolated rat heart compared with thiamylal,” Japanese Heart Journal, vol. 42, no. 2, pp. 193–206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Yamanaka and Y. Hayashi, “Myocardial preconditioning in anesthesia: from bench to bedside,” Masui, vol. 58, pp. 279–287, 2009. View at Google Scholar
  29. Z. Xia, D. V. Godin, and D. M. Ansley, “Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F2t-isoprostane formation and tissue antioxidant capacity,” Cardiovascular Research, vol. 59, no. 1, pp. 113–121, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Li, Z. Liu, J. Wang et al., “Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats,” Cardiovascular Diabetology, vol. 12, no. 1, article 133, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Xia, K.-H. Kuo, D. V. Godin, M. J. Walker, M. C. Y. Tao, and D. M. Ansley, “15-F2t-isoprostane exacerbates myocardial ischemia-reperfusion injury of isolated rat hearts,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 289, no. 4, pp. H1366–H1372, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. Z. Guo, Z. Xia, J. Jiang, and J. H. McNeill, “Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 292, no. 4, pp. H1728–H1736, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. J. D. Morrow, T. A. Minton, C. R. Mukundan et al., “Free radical-induced generation of isoprostanes in vivo: evidence for the formation of D-ring and E-ring isoprostanes,” The Journal of Biological Chemistry, vol. 269, no. 6, pp. 4317–4326, 1994. View at Google Scholar · View at Scopus
  34. J. Nourooz-Zadeh, “Gas chromatography-mass spectrometry assay for measurement of plasma isoprostanes,” Methods in Enzymology, vol. 300, pp. 13–17, 1999. View at Publisher · View at Google Scholar
  35. F. G. Spinale, J. D. Walker, R. Mukherjee, J. P. Iannini, A. T. Keever, and K. P. Gallagher, “Concomitant endothelin receptor subtype-A blockade during the progression of pacing-induced congestive heart failure in rabbits: beneficial effects on left ventricular and myocyte function,” Circulation, vol. 95, no. 7, pp. 1918–1929, 1997. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Xia, J. Gu, D. M. Ansley, F. Xia, and J. Yu, “Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease,” Journal of Thoracic and Cardiovascular Surgery, vol. 126, no. 5, pp. 1404–1410, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. D. M. Ansley, Z. Xia, and B. S. Dhaliwal, “The relationship between plasma free 15-F2t-isoprostane concentration and early postoperative cardiac depression following warm heart surgery,” Journal of Thoracic and Cardiovascular Surgery, vol. 126, no. 4, pp. 1222–1223, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. H.-M. Liu, K.-X. Liu, M.-H. Cheng et al., “Bosentan affects 15-F2t-isoprostane adverse effects on postischemic rat hearts,” Journal of Surgical Research, vol. 168, no. 1, pp. 18–26, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Kuang, M. Febbraio, C. Wagg, G. D. Lopaschuk, and J. R. B. Dyck, “Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia,” Circulation, vol. 109, no. 12, pp. 1550–1557, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. J. R. Ussher and G. D. Lopaschuk, “Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion,” Basic Research in Cardiology, vol. 104, no. 2, pp. 203–210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Wang, K. W. S. Ko, E. Lucchinetti et al., “Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty acid and glucose oxidation: CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift,” Anesthesiology, vol. 113, no. 3, pp. 541–551, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. P. G. Murphy, D. S. Myers, M. J. Davies, N. R. Webster, and J. G. Jones, “The antioxidant potential of propofol (2,6-diisopropylphenol),” British Journal of Anaesthesia, vol. 68, no. 6, pp. 613–618, 1992. View at Publisher · View at Google Scholar · View at Scopus
  43. S. G. de Hert, P. W. ten Broecke, E. Mertens et al., “Sevoflurane but not propofol preserves myocardial function in coronary surgery patients,” Anesthesiology, vol. 97, no. 1, pp. 42–49, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. P. C. A. Kam and D. Cardone, “Propofol infusion syndrome,” Anaesthesia, vol. 62, no. 7, pp. 690–701, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. N. Kokita, A. Hara, Y. Abiko, J. Arakawa, H. Hashizume, and A. Namiki, “Propofol improves functional and metabolic recovery in ischemic reperfused isolated rat hearts,” Anesthesia & Analgesia, vol. 86, no. 2, pp. 252–258, 1998. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Jovic, A. Stancic, D. Nenadic et al., “Mitochondrial molecular basis of sevoflurane and propofol cardioprotection in patients undergoing aortic valve replacement with cardiopulmonary bypass,” Cellular Physiology and Biochemistry, vol. 29, no. 1-2, pp. 131–142, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. C. Pantos, A. Bescond-Jacquet, S. Tzeis et al., “Trimetazidine protects isolated rat hearts against ischemia-reperfusion injury in an experimental timing-dependent manner,” Basic Research in Cardiology, vol. 100, no. 2, pp. 154–160, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Ikizler, N. Erkasap, S. Dernek, B. Batmaz, T. Kural, and Z. Kaygisiz, “Trimetazidine-induced enhancement of myocardial recovery during reperfusion: a comparative study in diabetic and non-diabetic rat hearts,” Archives of Medical Research, vol. 37, no. 6, pp. 700–708, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. G. D. Lopaschuk, R. Barr, P. D. Thomas, and J. R. B. Dyck, “Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase,” Circulation Research, vol. 93, no. 3, pp. e33–e37, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. G. Fragasso, A. Salerno, G. Lattuada et al., “Effect of partial inhibition of fatty acid oxidation by trimetazidine on whole body energy metabolism in patients with chronic heart failure,” Heart, vol. 97, no. 18, pp. 1495–1500, 2011. View at Publisher · View at Google Scholar · View at Scopus