Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China

Table 2

Association of 28 SNPs tested with T2D in a Mongolian sample.

Chromosome	Nearby gene	SNP	Risk allele	Risk allele frequency		value	OR	OR L95^a	OR H95^b
				Cases	Controls
2	IRS1	rs7578326	A	0.843	0.792	6.4E − 08	1.27	0.98	1.64
12	HMGA2	rs1531343	C	0.111	0.106	6.2E − 07	1.08	0.79	1.49
15	PRC1	rs8042680	A	0.953	0.916	5.6E − 06	1.32	0.86	2.00
2	THADA	rs7578597	T	0.989	0.980	8.0E − 06	1.92	0.76	4.76
9	CDKN2	rs1333051	A	0.836	0.833	7.3E − 05	1.05	0.80	1.39
2	TMEM163	rs6723108	T	0.997	0.980	7.9E − 05	7.69	2.00	33.33
11	KCNQ1	rs2237897	C	0.676	0.585	8.7E − 05	1.39	1.11	1.72
11	KCNQ1	rs163182	C	0.427	0.358	1.0E − 04	1.37	1.11	1.69
11	MTNR1B	rs1387153	T	0.420	0.358	2.7E − 04	1.17	0.95	1.44
2	BCL11A	rs243021	A	0.715	0.696	1.2E − 04	1.33	1.06	1.67
7	PAX4	rs10229583	G	0.848	0.817	4.5E − 04	1.28	0.97	1.69
3	IGF2BP2	rs4402960	T	0.320	0.274	5.0E − 02	1.21	0.97	1.50
2	GRB14	rs3923113	A	0.847	0.812	1.7E − 02	1.20	0.93	1.56
13	SPRY2	rs1359790	G	0.698	0.679	9.9E − 03	1.18	0.95	1.47
3	ADAMTS9	rs4607103	C	0.594	0.566	1.2E − 01	1.11	0.88	1.39
11	KCNJ11	rs5215	C	0.370	0.336	6.1E − 03	1.03	0.84	1.25
10	HHEX-IDE	rs5015480	C	0.223	0.219	5.7E − 03	1.01	0.80	1.29
10	TCF7L2	rs7903146	T	0.053	0.061	1.1E − 01	1.01	0.66	1.57
11	CENTD2	rs1552224	A	0.896	0.891	5.3E − 02	1.00	0.72	1.39
15	RASGRP1	rs7403531	T	0.375	0.359	2.5E − 02	0.98	0.80	1.20
4	WFS1	rs1801214	T	0.947	0.943	5.8E − 02	0.98	0.62	1.54
16	FTO	rs8050136	A	0.162	0.166	1.3E − 01	0.98	0.75	1.30
8	TP53INP1	rs896854	T	0.351	0.389	3.1E − 02	0.93	0.76	1.15
12	LGR5	rs7961581	C	0.219	0.239	6.1E − 02	0.92	0.72	1.17
10	GRK5	rs10886471	C	0.755	0.774	2.2E − 02	0.86	0.67	1.10
6	C6orf57	rs1048886	G	0.148	0.212	1.2E − 04	0.67	0.51	0.89
15	ZFAND6	rs11634397	G	0.178	0.231	2.6E − 05	0.67	0.52	0.86
5	ZBED3	rs4457053	G	0.055	0.090	1.4E − 02	0.63	0.43	0.94

Lower boundary of 95% confidence interval (CI) of odd’s ratio.
^bUpper boundary of 95% CI of odd’s ratio.