Journal of Diabetes Research

Research Article

Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China

Table 3

Comparison of risk allele frequency of 28 SNPs tested for association with T2D in a Mongolian sample against 1000G populations.


Nearby gene	SNP	T2D risk allele	T2D risk allele frequency				(MGL − CEU)/CEU	with Mongolian sample			T2D association
Nearby gene	SNP	T2D risk allele	MGL^a	CEU^b	CHS^c	CHB^d	(MGL − CEU)/CEU	CEU	CHS	CHB	T2D association

TMEM163	rs6723108	T	0.98	0.51	1.00	1.00	0.94	0.66	0.01	0.01	Yes
C6orf57	rs1048886	G	0.21	0.14	0.06	0.10	0.55	0.01	0.07	0.04	No
WFS1	rs1801214	T	0.94	0.65	0.88	0.98	0.46	0.34	0.03	0.01	No
BCL11A	rs243021	A	0.70	0.48	0.66	0.63	0.45	0.06	0.23	0.19	Yes
MTNR1B	rs1387153	T	0.36	0.25	0.45	0.41	0.42	0.02	0.02	0.00	Yes
GRK5	rs10886471	C	0.77	0.55	0.76	0.79	0.42	0.21	0.00	0.00	No
GRB14	rs3923113	A	0.81	0.59	0.89	0.81	0.37	0.12	0.02	0.00	No
RASGRP1	rs7403531	T	0.36	0.28	0.29	0.34	0.29	0.01	0.01	0.00	No
PRC1	rs8042680	A	0.92	0.72	1.00	1.00	0.28	0.67	0.05	0.04	Yes
IRS1	rs7578326	A	0.79	0.66	0.83	0.86	0.20	0.04	0.00	0.01	Yes
THADA	rs7578597	T	0.98	0.88	0.99	1.00	0.12	0.13	0.00	0.00	Yes

PAX4	rs10229583	G	0.82	0.75	0.84	0.84	0.09	0.01	0.00	0.00	Yes
CENTD2	rs1552224	A	0.89	0.88	0.91	0.90	0.01	0.00	0.00	0.00	No
HMGA2	rs1531343	C	0.11	0.11	0.12	0.11	0.00	0.00	0.00	0.00	Yes
CDKN2	rs1333051	A	0.83	0.84	0.88	0.86	−0.01	0.00	0.00	0.00	Yes
SPRY2	rs1359790	G	0.68	0.73	0.70	0.67	−0.07	0.00	0.00	0.00	No
LGR5	rs7961581	C	0.24	0.26	0.21	0.19	−0.09	0.00	0.00	0.00	No
TP53INP1	rs896854	T	0.39	0.43	0.30	0.31	−0.09	0.00	0.02	0.01	No

IGF2BP2	rs4402960	T	0.27	0.31	0.23	0.25	−0.11	0.00	0.00	0.00	No
KCNJ11	rs5215	C	0.34	0.38	0.40	0.38	−0.12	0.00	0.00	0.00	No
KCNQ1	rs163182	C	0.36	0.41	0.31	0.39	−0.13	0.00	0.00	0.00	Yes
ADAMTS9	rs4607103	C	0.57	0.78	0.64	0.57	−0.28	0.09	0.01	0.00	No
ZFAND6	rs11634397	G	0.23	0.34	0.07	0.08	−0.33	0.33	0.07	0.06	No
KCNQ1	rs2237897	C	0.58	0.94	0.66	0.62	−0.38	0.23	0.01	0.00	Yes
FTO	rs8050136	A	0.17	0.44	0.14	0.15	−0.63	0.19	0.00	0.00	No
ZBED3	rs4457053	G	0.09	0.30	0.04	0.07	−0.70	0.17	0.01	0.00	No
TCF7L2	rs7903146	T	0.06	0.31	0.03	0.02	−0.81	0.27	0.01	0.01	No

Mongolian sample of this study. ^b,c,dPopulation samples of Caucasian, Chinese in Beijing, and Chinese in Shanghai from the 1000G project, respectively.