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Journal of Diabetes Research
Volume 2015, Article ID 803986, 9 pages
Research Article

Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway

1Diabetes Center, Shenzhen University, Shenzhen 518060, China
2University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

Received 11 March 2015; Accepted 29 April 2015

Academic Editor: Shao-Nian Yang

Copyright © 2015 Xiangchen Kong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary data showed that FLZ decreased PDX-1 cytosolic localization (Suppl.Fig.1), in contrast, it increased FOXO1 cytosolic localization (Suppl.Fig.2). MK-2206 inhibited PDX-1 expression and nuclear localization induced by FLZ (Suppl.Fig.3). MK-2206 had no effect on cell viability, insulin content and secretion in INS-1E cells at G30 (Suppl.Fig.4).

  1. Supplementary Material