In Vitro and In Vivo Effects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue
The results of morphometric analyses: comparison of the adipocytes size (a) and areas (b) in tissue of control and experimental group. Differences in cells dimensions were statistically significant at (). Morphometric analysis of adipocytes was performed on six sections separately. Calculations were expressed as a mean value (-axis). (c) The results of hematoxylin-eosin (H-E) staining of adipose tissue sections derived from control group (A) and experimental group (B). Diversity of adipocytes in tissue of mice treated with metformin was indicated with arrows: red is indicating cells smaller in size and black is indicating cells of larger size. Scale bar is 75 μm. (d) The results of crown-like structures determination performed on six different microscopic images. Crown-like structures are visible in sections as aggregated macrophages accumulated and fused around adipocytes.
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