Effects of E2HSA, a Long-Acting Glucagon Like Peptide-1 Receptor Agonist, on Glycemic Control and Beta Cell Function in Spontaneous Diabetic db/db Mice
Chronic treatment with E2HSA normalized islet morphology, increased β-cell area, and inhibited β-cell apoptosis in spontaneous type 2 diabetes db/db mice. (a) Immunofluorescence double staining with anti-insulin and anti-glucagon antibodies on pancreatic sections. (b) TUNEL assay on β-cells costained with anti-insulin antibodies. Representative images are shown. (c) Total β-cell area as percentage of total islet areas (). (d) Percentage of TUNEL positive β-cells in insulin positive cells ( per group). Data are expressed as mean ± S.E.M. and versus Con.
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