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Journal of Diabetes Research
Volume 2015, Article ID 841768, 9 pages
Research Article

Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes

1Department of Environmental Health, School of Public Health, Nantong University, Nantong, Jiangsu 226000, China
2Department of Comprehensive Statistics, The Third People’s Hospital of Nantong, Nantong, Jiangsu 226000, China
3Department of Computer Science, School of Computer Science and Technology, Nantong University, Nantong, Jiangsu 226000, China
4Department of Chronic Non-Communicable Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China

Received 22 April 2015; Accepted 23 June 2015

Academic Editor: Andrea Tura

Copyright © 2015 Chun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to evaluate the associations between chronic smoking and insulin resistance and β-cell function in Chinese men without diabetes. A total of 1,568 participants were recruited by multistage sampling. Using homeostatic model assessment (HOMA), geometric means of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) with 95% confidence interval (CI) were calculated by general linear model. Odds ratios (ORs) with 95% CI were estimated to evaluate the associations between smoking status and insulin resistance and β-cell deficiency under a logistic regression model. Current smokers had higher levels of 2 h glucose (6.66 versus 6.48 mmol/L) for oral glucose tolerance test and lower levels of fasting insulin (5.68 versus 6.03 mU/L) than never smokers. The adjusted means for HOMA-β (%) were 54.86 in current smokers and 58.81 in never smokers (). Current smoking was associated with β-cell deficiency (OR 1.29, 95% CI 1.01–1.64) compared to never smoking. The β-cell function gradually decreased with increasing smoking intensity (), and the differences were statistically significant when the pack-year of smoking was 20 or above. No association was observed between smoking status and HOMA-IR. Our study suggested that chronic smoking may dose-dependently suppress insulin secretion in Chinese men.