The PI3K/Akt Signaling Pathway Mediates the High Glucose-Induced Expression of Extracellular Matrix Molecules in Human Retinal Pigment Epithelial Cells
The PI3K/Akt signaling pathway mediated the mRNA expression of fibronectin, collagen IV, and laminin in RPE cells under high glucose conditions. (a, b, c) After pretreatment with 20 μM LY294002 for 12 h, the mRNA expression of fibronectin, collagen IV, and laminin was significantly decreased when exposed to high glucose conditions for 24 h in RPE cells. versus NG or . The data shown represent the of three independent experiments.