The PI3K/Akt Signaling Pathway Mediates the High Glucose-Induced Expression of Extracellular Matrix Molecules in Human Retinal Pigment Epithelial Cells

Figure 6

The protein level of fibronectin, collagen IV, and laminin was mediated by PI3K/Akt signaling pathway in RPE cells under high glucose conditions. (a, b, c) The protein expression of fibronectin, collagen IV, and laminin was significantly decreased when exposed to high glucose conditions for 24 h in RPE cells by pretreatment with 20 μM LY294002 for 12 h. versus NG or . The data shown represent the of three independent experiments.

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