Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
Table 3
Genotype distribution of PPARGC1A SNPs by ethnicity and T2D.
SNPs
Minor allele
Haitian Americans (n = 226)
African Americans (n = 246)
Cases (n = 110)
Controls (n = 116)
-value
MAF (%)
Cases (n = 124)
Controls (n = 122)
value
MAF (%)
Cases
Controls
Cases
Controls
Genotype frequencies (, %)
rs8192678
CC
92 (84)
102 (88)
103 (84)
104 (85)
CT
T
4 (4)
14 (12)
0.000
0.145
0.060
19 (15)
18 (15)
0.365
0.093
0.074
TT
14 (13)
0 (0)
2 (2)
0 (0)
rs7656250
TT
85 (73)
96 (83)
90 (72)
98 (80)
CT
C
24 (22)
19 (16)
0.579
0.118
0.090
27 (22)
21 (17)
0.263
0.165
0.110
CC
1 (0.9)
1 (0.8)
7 (6)
3 (2)
rs4235308
TT
35 (32)
52 (45)
56 (45)
51 (42)
CT
C
59 (54)
52 (45)
0.124
0.441
0.327
51 (41)
60 (49)
0.327
0.343
0.336
CC
16 (14)
12 (10)
17 (14)
11 (9)
rs11724368
CC
93 (84)
100 (86)
103 (83)
105 (86)
CG
G
17 (15)
16 (14)
0.724
0.072
0.069
19 (15)
17 (14)
0.347
0.093
0.069
GG
0 (0)
0 (0)
2 (2)
0 (0)
Note: genotype frequencies are depicted as (%). Cases: with T2D; controls: without T2D; SNP: single nucleotide polymorphism; MAF: minor allele frequency.