Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study
Table 1
Characteristics of 6520 participants in the ADDITION-Leicester cross-sectional screening study stratified by baseline serum potassium level.
K+ quartile
Characteristic
Total Cohort
<4.0 mmol/L ()
4.0–4.2 mmol/L ()
4.3–4.4 mmol/L ()
≥4.5 mmol/L ()
for trenda
N
%
N
%
N
%
N
%
N
%
Female
3429
52.6
710
54.8
1084
58.9
692
53.0
943
45.4
≤0.001
Diuretics/thiazides
648
9.6
258
39.8
204
31.5
73
11.3
112
17.3
0.192
ACE-inhibitors
424
6.3
95
22.4
97
22.9
73
17.2
158
37.3
0.643
beta-blockers
619
9.2
125
20.2
154
24.9
113
18.3
226
36.5
0.630
Angiotensin-II receptor antagonists
223
3.3
58
26.0
59
26.5
35
15.7
70
31.4
0.542
Mean
SD
Mean
SD
Mean
SD
Mean
SD
Mean
SD
Age (years)
56.0
10.8
56.3
10.9
55.4
10.9
55.6
10.8
56.7
10.6
0.061
BMI (kg/m2)
28.1
5.0
28.0
5.2
28.0
5.1
27.9
4.7
28.2
5.0
0.317
Waist circumference (cm)
93.9
13.1
93.7
14.1
93.0
13.3
93.5
12.1
95.0
12.9
≤0.001
Systolic blood pressure (mmHg)
136.9
19.6
136.5
20.1
136.4
19.5
136.1
19.2
138.0
19.6
0.023
Diastolic blood pressure (mmHg)
85.4
10.6
84.9
11.0
85.3
10.5
85.0
10.3
85.9
10.6
0.022
EGFR
75.8
13.2
75.7
12.8
76.4
13.5
76.0
12.6
75.2
13.3
0.061
2-hour glucose (mmol/L)
6.0
2.4
6.4
2.4
6.1
2.4
5.9
2.3
5.9
2.4
≤0.001
Fasting blood glucose (mmol/L)
5.2
0.9
5.2
1.0
5.2
1.0
5.2
0.8
5.2
0.8
0.483
HbA1c (%)
5.7
0.6
5.6
0.6
5.7
0.6
5.7
0.5
5.8
0.6
≤0.001
K+ (mmol/L)
4.3
0.4
3.7
0.2
4.1
0.1
4.3
0.1
4.7
0.2
≤0.001
values for trend were estimated using logistic or linear regression and test whether there is a linear trend in the outcome across potassium categories. SD: standard deviation and eGFR: estimated glomerular filtration rate (Cockroft-Gault formula).
