Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insulin Resistance in Dyslipidemic Female LDL Receptor Knockout Mice

Figure 1

Circulating levels of lipids, glucose, and insulin in Ldlr^−/− mice fed a chow, HF, or HFC diet for 2 weeks. Body weight (a) and liver weight (b) of WT and Ldlr^−/− mice fed a chow, high-fat (HF), or high-fat cholesterol (HFC) diet were determined at time of sacrifice (). Plasma triglyceride (c), cholesterol (d), glucose (e), and insulin (f) levels were measured in blood obtained following a 6-hour fast ( = 5-6). (g) The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from fasted insulin and glucose levels (). Data are expressed as means ± SEM for WT mice (white bars) and Ldlr^−/− mice (black bars). WT versus KO; ^# HF, HFC versus chow; HF versus HFC.

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