Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insulin Resistance in Dyslipidemic Female LDL Receptor Knockout Mice

Figure 3

Absence of adipose tissue inflammation in Ldlr^−/− mice fed a chow, HF, or HFC diet for 2 weeks. Representative pictures of paraffin-embedded white adipose tissue sections stained with hematoxylin-eosin (a) were taken from WT and Ldlr^−/− mice fed a chow, HF, or HFC diet ( = 5-6). RNA was isolated from white adipose tissue and the expression of the proinflammatory genes Cd68 (b), Cd11b (c), Tnfa (d), and Mcp1 (e) was determined by real-time PCR and expressed as fold induction (-12). Data are expressed as means ± SEM for WT mice (white bars) and Ldlr^−/− mice (black bars).

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