Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insulin Resistance in Dyslipidemic Female LDL Receptor Knockout Mice

Figure 5

Differences in hepatic lipid accumulation cannot explain hepatic insulin resistance. To assess hepatic lipid accumulation, we measured levels of triglycerides (a) cholesterol (b), free cholesterol (c), and 1,2 DAG (d) in liver tissue of WT and Ldlr^−/− mice fed a chow, high-fat (HF), or high-fat cholesterol (HFC) diet. Data are expressed as means ± SEM for WT mice (white bars) and Ldlr^−/− mice (black bars) (). versus wild type. , WT versus KO; ^# HF, HFC versus chow; , HF versus HFC.

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