Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice

Figure 3

Effects of histamine, CB, and 4-MH on diabetes onset in NOD mice. (a) Effects of histamine deficiency in HDC^−/− mice on diabetes onset versus WT controls. Diabetes prevention in NOD HDC^−/− mice treated with histamine (4 mg/kg, i.p. injection, once a week for 10 weeks) (; , each group). Mice were measured as diabetic when glycemia >2.5 g/L. (b) Similar experiment performed with NOD HDC^+/+ mice (; , each group). (c) Mean fluorescnce intensity of MHCII, CD80, and CD86 molecules on mPDCA1⁺CD11c^low pDCs (; mean ± s.d., per group). Effects of CB (d) and 4-MH (e) on diabetes onset in WT mice (, each group).

(a)

(b)

(c)

(d)

(e)